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Clinical Studies


Medifast provides a comprehensive weight management approach that is both effective and safe. The program is backed by a Scientific Advisory Board comprised of accomplished experts in weight management.

Clinical evidence of Medifast’s safety and effectiveness has been proven in studies conducted by researchers from leading university teaching hospitals, including Johns Hopkins University

These studies confirm why Medifast, the brand, has been recommended by over 20,000 doctors since 1980 and used by over one million customers since then.

Clinical Study #1


Efficacy of a meal replacement diet compared to a food-based diet after a period of weight loss and weight maintenance: a randomized controlled trial. Davis, L.M., et al. (2010). Nutrition Journal, 9(11).

Objective: To determine the effect of Medifast’s meal replacement program on body composition, body weight, and biomarkers of inflammation and oxidative stress among obese individuals following a period of weight loss and weight maintenance compared to an isocaloric, food-based diet.Female-Doctor-picture1-199x300

Synopsis: This was a 40 week randomized, controlled clinical trial with 90 obese adult participants assigned to each group (Medifast or food-based) for 16 week  and then maintenance for 24 weeks. Numerous  outcomes were measured regularly including weight, vital signs, % body fat and  lean muscle mass. Blood lipids along with markers of inflammation and oxidative stress were measured at baseline, 16 weeks and 40 weeks.

Results: Weight loss at 16 weeks  was  significantly better in the Medifast group versus the food based group and overall greater weight loss was achieved at the 40 week endpoint. Additionally, the Medifast group saw significant improvements in body composition compared with the food based group at both weeks 16 and 40. There was also a significant decrease in urine lipid peroxide levels not seen in the food based group. Both groups saw a significant decrease in the inflammatory marker levels.

Conclusion: The data suggests that the Medifast plan was effective for generating robust initial weight loss, and then producing improvements in numerous health related parameters during maintenance including inflammation and oxidative stress. The authors noted these factors have been shown to underlie common chronic diseases.

Clinical Study #2 (Type 2 Diabetes Study)


Efficacy of meal replacements versus a standard food-based diet for weight loss in type 2

diabetes: a controlled clinical trial. Cheskin, L.J., et al. (2008). The Diabetes Educator, 34(1), 118-127.

Objective: To evaluate the effectiveness of a portion-controlled meal replacement diet to a standard diet (based on recommendations by the American Diabetes Association) in achieving and maintaining weight loss among obese men and women with type 2 diabetes mellitus.Diabetes-picture-274x300

Synopsis: Study performed at Johns Hopkins University comparing 119 adults with type 2 diabetes and body mass index (BMI) between 25 and 40 kg/m2, and were randomized into one of  two   34 week programs where caloric intake was reduced to 75% of predicted energy needs. One group was given  meal replacements while the other group was a food based diet. The groups were then followed for one year of weight maintenance.

Results: At the conclusion of the 34 weeks, weight loss and BMI reductions were significantly greater on the meal replacement diet. The ease of adherence and retention rates (57% vs 29%) were also higher in the meal replacement group throughout the study. Of those who started and then completed the study using medications for type 2 diabetes,  24% of the meal replacement group were able to reduce their diabetes medication versus 0% in the food based group.

Conclusion: The meal replacement group was more likely to complete the program, lose twice the amount of weight and experience less weight regain after the maintenance phase. In addition, the meal replacement program helped those with type 2 diabetes decrease medication use. The authors advised that health professionals should consider meal replacements as part of a comprehensive approach for weight management with those who are diagnosed with type 2 diabetes.


Clinical Study #3


Effectiveness of Medifast supplements combined with obesity pharmacotherapy: a clinical program evaluation. Haddock, C.K., et al. (2008). Eating and Weight Disorders, 13(2), 95-101.

Objective: To evaluate the long-term impact of Medifast meal replacement supplements (MMRS) combined with appeObesity-Beach-Picture-300x217tite suppressant medication (ASM) among participants who received 52 weeks of treatment as part of a medically supervised weight-control program.

Synopsis: This was a systematic program evaluation from a medically supervised weight control program looking at 1351 patients’ medical charts with at least 12 weeks of treatment. Participants had a BMI greater than 25 kg/m2.  Outcomes included weight loss and % weight loss at 12, 24, and 52 weeks..

Results: For those who completed the 52 weeks of treatment, weight loss was substantial at 12 (-20.7 +/- 12.5 lbs), 24 (-26.4 +/- 17.8 lbs) and 52 (27.3 +/- 20.2 lbs) weeks. All changes were significant compared to baseline weight at all time points. At 24 weeks,, 50% were still in the program and 25% were still participating when the 52 week treatment period ended.

Conclusion: The weight loss program produced significant and sustained weight loss at the conclusion of the 52 week treatment. Results were better than those typically reported for either partial meal replacement programs or obesity pharmacotherapy. The authors noted similar program retention to many controlled drug trials and better than most commercial programs in the literature.


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Not only are there FIVE Reasons to choose Medifast Weight Control Centers, there are also FOUR Locations Valleywide at your service.

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Call today and receive a Free Consultation along with a Complimentary In-Body Body Composition Analysis at any one of our four Arizona Medifast Weight Control Centers.

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